ABSTRACT
Adiponectin is one of the adipokines derived from adipose tissue. It is involved in the regulation of glucose metabolism, Insulin Resistance [IR] and obesity-related disorders. Adiponectin in patients with Poly Cystic Ovarian Syndrome [PCOS] has a different expression. This study was performed to assess the serum levels of adiponectin in PCOS patients considering the high prevalence of insulin resistance in this patients and its relation with body mass index, fasting insulin and fasting glucose to evaluate This case-control study was performed on 45 PCOS patients and 45 controls being matched in regards to age and BMI. Adinopectin level was measured by ELISA. FBS and insulin were measured by glucose oxidase and ELISA method, respectively. Insulin resistance was determined by HOMA-IR. Serum adiponectin level in PCOS subjects and healthy women did not differ statistically. There was no significant difference between fasting insulin and fasting glucose levels in PCOS subjects and healthy women. However, HOMA-IR in PCOS subjects was significantly higher than healthy women. There was a significant negative correlation between adiponectin level and BMI [p=0.035] and fasting glucose [p=0.019]. However, after separation of the two groups there was no correlation between adiponectin and BMI. Despite the relationship between adiponectin levels and BMI, and as no relation is observed with PCOS, the role of this adipokine in the syndrome is unlikely. Thus, apparently increase in the amount of adiponectin will not be effective in preventing the syndrome
ABSTRACT
Adipokines are proteins secreted from adipose tissue that are involved in metabolism control. Adipsin is one of the adipokines that has a systemic role in lipid metabolism or physiological systems relating to energy balance. Serum levels are found to be associated with BMI, and insulin resistance in several studies. The aim of this study was to assess adipsins association with Poly Cystic Ovary Syndrome [PCOS]. This case-control study was performed on patients who referred to the clinic of the Research Institute for Endocrine Sciences of Shahid-Beheshti University in 2011. Forty five patients with PCOS and 45 normal individuals as control group were selected by easy given sampling method and studied. Fasting adipsin and insulin serum levels were measured by Elisa method and fasting glucose serum level was measured by enzyme-calorimetric method. Data were analyzed using independent t-test, Pearson correlation coefficient and one-way ANOVA by SPSS 16 software. Adipsin serum levels did not correlate with insulin resistance in PCOS [15.93 +/- 7.24 ng/dl in PCOS patients and 14.21 +/- 7.53 ng/dl in control group]. Glucose and insulin serum levels increased in PCOS [104.1 +/- 13.4 mg/dl and 10.8 +/- 5.2 mU/L respectively] in comparison with controls and these PCOS patients had insulin resistance. This study does not show the correlation between adipsin level and PCOS. It is possible to find a relationship between PCOS and adipsin through expanding the population or limiting the age levels
ABSTRACT
Adipokines are proteins which are secreted from the adipose tissue. These groups of proteins are involved in the control of metabolism. Chemerin is one of these adipokines with different proposed biological roles. Serum levels of chemerin have been associated with increased body mass index, insulin resistance, metabolic syndrome, diabetes and cardiovascular diseases. The aim of this study was to assess the association between serum chemerin concentrations and polycystic ovarian syndrome. This case-control study was performed in Taleghani Hospital in Tehran, Iran during 2011. On 45 patients with polycystic ovarian syndrome and 45 normal individuals as the control group. The participants were selected by easy given sampling method. Body mass index, fasting chemerin and serum insulin concentrations were measured by Enzyme-Linked Immunosorbent Assay [ELIZA] method. Fasting serum glucose was measured by the enzyme-calorimetric method and insulin resistance index [HOMA-IR] was measured by the calculation of relevant equation. Data was analyzed using independent t-test and Pearson's correlation coefficient by SPSS version 18. Serum chemerin, insulin, and glucose concentrations were significantly higher in patients with polycystic ovarian syndrome than the control group. There was no significant correlation between body mass index, serum levels of insulin, glucose, HOMA-IR, or chemerin in cases and controls. This study showed that serum chemerin levels increase in polycystic ovarian syndrome. The findings also suggest that changes in chemerin serum levels could be considered as a criterion for polycystic ovarian syndrome